The Synthesis of 8-Substituted Purine Derivatives. I. Some 8-Substituted Derivatives of Hypoxanthine.
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چکیده
منابع مشابه
Synthesis and Antithyroid Activity of Some 8-Substituted Purine Derivatives
Some novel as well as known derivatives of 8-sulfanyl-3,9dihydro-1H-purine-2,6-dione were synthesized and their antithyroid activity was measured in rats after administration of a daily dose of 20mg/kg via i.p. injection for 15 days. Free thyroxine and triiodothyronine concentrations were determined using radioimmunoassay technique. The assay results showed decrease in the hormonal concentratio...
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Bacterial luciferase catalyzes the emission of visible light from the reaction of reduced flavin, molecular oxygen, and an n-alkyl aldehyde. The mechanism of the reaction was probed by measuring the electronic effects of various substituents at the 8-position of the flavin ring system. Substituent effects were obtained for CH3-, Cl-, CH3O-, CH3S-, F-, and H- on the rate of formation and decay o...
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ژورنال
عنوان ژورنال: Pharmaceutical Bulletin
سال: 1957
ISSN: 0369-9471,1881-1345
DOI: 10.1248/cpb1953.5.240